This College was established by the Medical & Health Department, Govt. of Rajasthan in 1965. On 17th July 1965, the first batch of 75 students was admitted. Subsequently, the number of admissions per year increased to 250. The first batch of this college graduated in 1969. That year, this college was named after the renowned educationalist, politician, and freedom fighter, Dr. Sampurnanand. In 1975, postgraduate courses commenced. At present, this Institute is conducting 21 PG courses for 111 students every year.
The college has an Auditorium, a Council Hall, and an air-conditioned Library including e-library. Lecture theatres including virtual class room with Audio-visual facilities, Laboratories for all non clinical subjects (Physiology, Biochemistry, Pathology, Microbiology) and a Dissection Hall for Anatomy are in place. Sports facilities include a Tennis Court, Badminton Court, a Cricket Ground, and a Swimming Pool.
The hospitals attached to Dr. SN Medical College are the Mahatma Gandhi Hospital, the Umaid Hospital, the Mathuradas Mathur Hospital, the Kamala Nehru TB & Chest Hospital, and the Psychiatric Hospital.