The hospital was originally built in commemoration of the visit of the Prince of Wales in 1875 and was named king Albert Edward Hospital. The Foundation stone was laid by sir. James Fergusson, then Governor of Bombay o 9 march 1877. This was possible the blessings of the regional ruler Chhatrapati Shahu Maharaj. This project was completed in 1881. The hospital underwent many changes after Shahu Maharaj returned from England and offered free treatment to every one. In 1946. The hospital renamed Chhatrapati Pramilatai Raje Hospital (CPR) in honor of Chhatrapati Pramilatai Raje, daughter in law of the Royal family of Kolhapur. In the year 2000, the hospital was officially affiliated to the newly established Rajarshee Chhatrapati Shahu Maharaj Government Medical College (RCSM GMC) & handed over to medical education department in 2007 from dept. of Health services.