K. J. Somaiya Medical College & Research Centre is a trust medical college in the heart of Mumbai, Maharashtra, India. The college was founded by Karamshi Jethabhai Somaiya and run by Somaiya trust. It has 50 undergraduate seats for MBBS matriculants.

It is situated in the Somaiya Ayurvihar Complex, a 22.5 acre campus located in central Mumbai. It is currently managed by the Somaiya Trust. The Charitable hospital is also a quarantine facility for COVID-19 patients.